Otto-von-Guericke-Universität Magdeburg



From retina to cognition: How does macular degeneration affect visual cognition?

The loss of foveal vision is a dramatic incision not only for the affected patients, but also for the visual system itself. As a reaction to the loss of the area of best vision, processes of reorganization have to take action in order to reduce the impairment of visual and cognitive capacities. Specifically, the formation of a new preferred retinal locus of fixation demands the accommodation of fixation-strategies, eye-movement programming, covert and overt exploration of the visual space, of of reading and visual search, and of mechanisms underlying visual object recognition and memory. In this joint project we aim at a detailed description of the retinal damage and its consequences on spatio-temporal cortical input and then investigate how higher visual and cognitive functions are adapted to the new situation to retain the visual and cognitive functionality of the system. The research project is designed to enhance our understanding of plastic processes of the visual system and is also of clinical relevance as maculopathies, in particular age-related macular degeneration (AMD), are the leading cause of legal blindness in Western nations.

The core aspect is to investigate which consequences a macular pathology bears on high-level aspects of vision, such as visual search, reading, deployment of visual attention and visual learning. As detailed in the sub-projects, we believe that a macular pathology does not only lead to basic visual deficits such as visual field defects and loss of acuity, but also to impairments in the guidance of eye-movements as well as of covert attention, in the distribution of spatial attention across the visual field and in the ability to use regularities in the visual environment to guide the exploration of our surroundings.

To address these topics, we intend to use a range of methods from sensory physiology, over reaction time and eye-movement analyses and mathematical modelling to functional magnetic resonance imaging (fMRI). These methods will be used in concert to follow the path of visual cognition from retinal pathology to subsequent visual processing changes and concomitant cortical activation changes.

Principal Investigators

Prof. Dr. Stefan Pollmann
Institut für Psychologie II, Lehrstuhl für Allgemeine Psychologie
Otto-von-Guericke-Universität Magdeburg

PD Dr. Michael Hoffmann
Sektion für Klin. und Exp. Sinnesphysiologie
Universitäts-Augenklinik Magdeburg

Prof. Dr. Gisela Müller-Plath
Institut für Psychologie und Arbeitswissenschaft
Psychologie Neuer Medien und Methodenlehre
TU Berlin

Prof. Dr. Ralf Engbert
Institut für Psychologie, Allgemeine und Biologische Psychologie
Universität Potsdam


Geringswald, F., Baumgartner, F. & Pollmann, S. (2012). Simulated loss of foveal vision eliminates visual search advantage in repeated displays. Frontiers in Human Neuroscience, 6, 134.

Geringswald F., Baumgartner F.J., Pollmann S. (2013). A behavioral task for the validation of a gaze-contingent simulated scotoma. Behavioral Research Methods, Mar 23. [Epub ahead of print].

Geringswald, F., Herbik, A., Hoffmann, M.B. & Pollmann, S. (2013). Contextual cueing impairment in patients with Age-Related Macular Degeneration. Journal of Vision, 13(3), 28; doi:10.1167/13.3.28

Herbik, A., Hölzl, C.G., Reupsch, J., Hoffmann, M.B. (2013). Differential effects of optic media opacities on mfERGs and mfVEPs. Clinical Neurophysiology 124, 1225-1231.

Herbik, A., Geringswald, F., Thieme, H., Pollmann, S. & Hoffmann, M.B. (2014). Prediction of higher visual function in macular degeneration with mfERG and mfVEP. Ophthalmic and Physiological Optics, 34, 540-551.

Geringswald, F., Herbik, A., Hofmüller, W., Hoffmann, M.B. & Pollmann, S. (2015). Visual memory for objects following foveal vision loss. Journal of Experimental Psychology: Learning, Memory, and Cognition, 41, 1471-1484.

Geringswald, F., & Pollmann, S. (2015). Central and peripheral vision loss differentially affects contextual cueing in visual search. Journal of Experimental Psychology: Learning, Memory, and Cognition, 41, 1485-1496.

Geringswald, F., Porracin, E. & Pollmann, S. (2016). Impairment of visual memory for objects in natural scenes by simulated central scotomata. Journal of Vision, 16, 6, 1-12.


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